Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes
نویسندگان
چکیده
منابع مشابه
Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes
BACKGROUND Shortly after stimulation by the preovulatory surge of luteinizing hormone (LH), oocytes arrested at the late prophase I resume meiosis characterized by germinal vesicle breakdown (GVBD), chromosome condensation, and extrusion of the first polar body in preparation for fertilization and early embryonic development. However, oocytes express few or no LH receptors and are insensitive t...
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BACKGROUND This study was conducted to investigate the fertilization and embryo development of human oocytes injected at different time intervals after extrusion of the first polar body (PB) following in vitro maturation (IVM) in IVM cycles. Also, we evaluated whether spindle imaging could serve as a tool to determine the optimal ICSI time. METHODS Oocytes were collected from 43 women with po...
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Asymmetric meiotic divisions in mammalian oocytes rely on the eccentric positioning of the spindle and the remodeling of the overlying cortex, resulting in the formation of small polar bodies. The mechanism of this cortical polarization, exemplified by the formation of a thick F-actin cap, is poorly understood. Cdc42 is a major player in cell polarization in many systems; however, the spatio-te...
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ژورنال
عنوان ژورنال: Reproductive Biology and Endocrinology
سال: 2009
ISSN: 1477-7827
DOI: 10.1186/1477-7827-7-26